Natural Killer Cells in Cancer Immunotherapy
نویسندگان
چکیده
منابع مشابه
Natural Killer T Cells in Cancer Immunotherapy
Natural killer T (NKT) cells are specialized CD1d-restricted T cells that recognize lipid antigens. Following stimulation, NKT cells lead to downstream activation of both innate and adaptive immune cells in the tumor microenvironment. This has impelled the development of NKT cell-targeted immunotherapies for treating cancer. In this review, we provide a brief overview of the stimulatory and reg...
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Invariant CD1d restricted natural killer T (iNKT) cells are regulatory cells that express a canonical TCR-Valpha-chain (Valpha24.Jalpha18 in humans and Valpha14.Jalpha18 in mice) which recognizes glycolipid antigens presented by the monomorphic CD1d molecule. They can secrete a wide variety of both pro-inflammatory and anti-inflammatory cytokines very swiftly upon their activation. Evidence for...
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ژورنال
عنوان ژورنال: Annual Review of Cancer Biology
سال: 2019
ISSN: 2472-3428,2472-3428
DOI: 10.1146/annurev-cancerbio-030518-055653